Contraindicated. Coadministration of doravirine with a robust CYP3A inducer might lessen doravirine plasma concentrations and/or effects. Prospective for lack of virologic response and achievable resistance to doravirine.
Immediately after stopping a CYP3A4 inducer, given that the effects of the inducer drop, the fentanyl plasma concentration will maximize which could raise or prolong both of those the therapeutic and adverse effects.
Watch Closely (1)pentobarbital will minimize the level or result of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
fentanyl intranasal and pentobarbital both of those raise sedation. Keep away from or Use Alternate Drug. Limit use to clients for whom option procedure options are insufficient
pentobarbital will reduce the extent or outcome of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or effect of apremilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration with powerful CYP inducers leads to a significant lessen of systemic exposure of apremilast, which can result in lack of efficacy
pentobarbital and daridorexant both maximize sedation. Modify Therapy/Observe Carefully. Coadministration will increase danger of CNS despair, which may result in additive impairment of psychomotor general performance and bring about daytime impairment.
pentobarbital will minimize the level or influence of etravirine by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.
pentobarbital will reduce the level or result check here of piroxicam by impacting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unidentified.
Contraindicated (1)pentobarbital will decrease the extent or result of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the extent or effect of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.
Watch Closely (three)pentobarbital will lower the extent or result of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Powerful or reasonable CYP3A4 inducers may possibly boost price of diazepam elimination; therefore, efficacy of diazepam could be diminished.
pentobarbital will decrease the extent or result of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
pentobarbital will reduce the level or result of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.